Existing ascii memcached clients (what most folks are using) should be able to connect to any gateway moxi instance or to any port-based moxi instance, without any changes. In your application's client library configuration, just specify the right port (eg, 11211, 11212, etc).
If an ascii memcached client connects to the gateway moxi, it will be assigned to use the "default" bucket (if the default bucket exists (it may have been deleted or not have been created by the Couchbase administrator)).
If an ascii memcached client connects to a port-based moxi (for example, port 11212 for the "shoppingCarts" bucket), it will be assigned to the bucket that was created with that port.