When you delete a replication, it stops replication from the source to the destination. If you re-create the replication between the same source and destination clusters and buckets, it XDCR will resume replication. To delete replication via REST API:

shell> curl -u Administrator:password1  \
http://10.4.2.4:8091/controller/cancelXCDR/9eee38236f3bf28406920213d93981a3%2Fbeer-sample%2Fremote_beer  \
-X DELETE

You use a URL-encoded endpoint which contains the unique document ID that references the replication. You can also delete a replication using the Couchbase Web Console. For more information, see Section 5.8.5, “Configuring Replication”.